ABSTRACT
Objective: To study the alkaloids from Ervatamia hainanensis. Methods: The alkaloids were isolated and purified by silica gel, MCI, Sephadex LH-20 column chromatography, and semi-preparative HPLC, and their structures were elucidated by physical and spectroscopic analysis. Results: Twelve alkaloids were obtained and identified as coronaridine (1), 19-epi-heyneanine (2), 9,10-dimethoxycoronaridine (3), vobasine (4), vobasine N(4)-oxide (5), 3-oxo-19-epi-heyneanine (6), strictamine (7), deacetylakuammiline (8), pandine (9), rhazicine (10), rhazicine N(4)-oxide (11), and rhazimine (12). Conclusion: Compounds 8 and 10-12 are isolated from the genus Ervatamia Stapf for the first time, while compounds 3 and 5-7 are firstly obtained from E. hainanensis.
ABSTRACT
Objective: To study the chemical constituents in the twigs and leaves of Ervatamia hainanensis. Methods: The chemical constituents were isolated by silica gel, ODS, Sephadex LH-20 column chromatographies, and preparative HPLC. The structures were elucidated on the basis of physicochemical properties and spectral analysis. Results: Four lignans were isolated and identified as threo-7-O-ethylguaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (1), threo-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (2), erythro-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (3), and dehydrodiconiferyl alcohol (4). Conclusion: Compound 1 is a new 8-O-4'-neolignan and named as hainanervaligan A (1), and compounds 2-4 are obtained from the plants of Ervatamia (A. DC.) Stapf for the first time.
ABSTRACT
Objective: To investigate the chemical constituents in the twigs and leaves of Ervatamia hainanensis. Methods: The chemical constituents were isolated by silica gel, Sephadex LH-20, and ODS columns, as well as RP-HPLC chromatography. Their structures were identified on the basis of physicochemical properties and spectral analyses. Results: Thirteen compounds were isolated and idenified as coronaridine (1), 19-heyneanine (2), 19-epi-heyneanine (3), coronaridine hydroxyindolenine (4), vobasine (5), ursolic acid (6), asiatic acid (7), 8α-hydroxypinoresinol (8), (+)-syringarosinol (9), ervatamisin [(-)-(7R, 7'R, 7″R, 8S, 8'S, 8″S)-4', 4″-dihydroxy-3, 3', 3″, 5-tetramethoxy-7, 9', 7', 9-diepoxy-4, 8″-oxy-8, 8'-sesquineolignan-7″, 9″-diol, 10], toddalolactone (11), threo-2, 3-bis-(4-hydroxy-3-methoxypheyl)-3-methoxy-propanol (12), and β-sitosterol (13). Conclusion: Compounds 6-8 and 10-12 are isolated from the plants of Ervatamia (A. DC.) Stapf for the first time, and compound 9 is firstly reported from E. hainanensis.
ABSTRACT
Objective To study indole alkaloids of Ervatamia hainanensis. Methods The compounds were separated and purified by column chromatography with silica gel and Sephadex LH-20. The structures were identified by IR, MS, and NMR. Results Seven alkaloids were identified as: hainanervatasine (Ⅰ), hainanervatacine (Ⅱ), vobasine (Ⅲ), coronaridine (Ⅳ), 3-hydroxyl coronaridine (Ⅴ), 3-(2-oxopropyl) coronaridine (Ⅵ), and tabernamine (Ⅶ), respectively. Conclusion Compounds Ⅰ and Ⅱ are new compounds. Compounds Ⅳ and Ⅵ are isolated from this plant for the first time.